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Latest Drugs
Infectious Diseases Drug Data - A-Z (English)
Drug Class Description
Genetically derived surface antigens (vaccines).Generic Name
Hepatitis BDrug Description
HB-Vax II: suspension in pre- filled syringe or vial. HB-Vax II 40: suspension in vial. HB-Vax II Paediatric: suspension in pre-filled syringe.Presentation
HB-Vax II: Hepatitis B surface antigen 10 microgram per mL adsorbed onto aluminium hydroxide. HB-Vax II 40: Hepatitis B surface antigen 40 microgram per mL adsorbed onto aluminium hydroxide. HB-Vax II Paediatric: Hepatitis B surface antigen 5 microgram per 0 .5 mL adsorbed onto aluminium hydroxide.Indications
HB-Vax II and HB-Vax II Paediatric: Active immunisation against hepatitis B virus. HB-Vax II 40: Active immunisation against hepatitis B virus in dialysis and predialysis dialysis and predialysis patients.
Adult Dosage
HB-Vax II: 1 L by intramuscular injection into the deltoid muscle, repeated 1 month and 6 months later.
Rapid immunisation, 1 mL by intramuscular injection, repeated 1 month, 2 months and 12 months later. HB-Vax II 40: 1 mL by intramuscular injection into the deltoid muscle, repeated 1 month and 6 months later.
Child Dosage
HB-Vax II and HB-Vax II Paediatric: Under 16 years, 0.5 mL by intramuscular injection into the deltoid muscle, repeated 1 month and 6 months later. Rapid immunisation, 0 .5 mL by intramuscular injection, repeated 1 month, 2 months and 12 months later. HB-Vax II 40: 1 mL by intramuscular injection into the deltoid muscle, repeated 1 month and 6 months later.Contra Indications
Severe febrile infections.Special Precautions
Dialysed or immunocompromised patients may need further doses. Severe cardiac or respiratory dysfunction. Pregnancy, lactation.Adverse Reactions
Mild transient local soreness, erythema and induration at injection site, low grade fever, malaise, rash, nausea, dizziness.Manufacturer
Aventis Pasteur MSDDrug Availability
(POM)Updated
24 June 2009Advert for Healthcare Professionals Only
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IlLLUMINATE trial of Incivek is published in NEJM Infectious Diseases Page
The New England Journal of Medicine (NEJM) published data from a Phase III study of Incivek(telaprevir) tablets in people with genotype 1 chronic Hepatitis C who were new to treatment. In ILLUMINATE, Incivek was given for the first 12 weeks in combination with pegylated-interferon and ribavirin. Nearly two-thirds of patients responded early to Incivek combination treatment (measured by having undetectable hepatitis C virus at weeks 4 and 12 of treatment) and were randomly assigned to receive an additional 12 weeks or 36 weeks of treatment with pegylated-interferon and ribavirin alone. Similarly high rates of sustained viral response (SVR, or viral cure) were achieved by people in both treatment groups. Rash and anemia were the most common side effects reported with Incivek in this study and each led to treatment discontinuation of all medicines in about 1 percent of people during the Incivek treatment phase. Data from ILLUMINATE are published in the September 15, 2011 issue of NEJM.
Incivek treatment still effective when course is half as long in treatment of Hepatitis C genotype 1 Infectious Diseases Page
A Phase III study (ADVANCE) of Incivek (telaprevir) tablets in patients with genotype 1 chronic Hepatitis C published in The New England Journal of Medicine (NEJM) reveals that a 24-week treatment course that adds Incivek to peginterferon alfa and ribavirin is just as effective as a 48-week regimen for many patients. Shortening the duration of treatment reduces a patient's exposure to side effects including rash and anemia.see Response-Guided Telaprevir Combination Treatment for Hepatitis C Virus Infection September 15, 2011Sherman K.E., Flamm S.L., Afdhal N.H., et al.N Engl J Med 2011; 365:1014 - 1024.
Vibativ is EU approved for nosocomial pneumonia caused by MNSA Infectious Diseases Page
Astellas and Theravance have received marketing authorisation from the European Commission for Vibativ (telavancin hydrochloride) for nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA).Its labelling will include its use in the treatment of adults with nosocomial pneumonia (hospital-acquired), including ventilator-associated pneumonia, known or suspected to be caused by MRSA when other alternatives are not suitable. In the US and Canada, the drug was approved in 2009 for the treatment of adult patients with complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of certain Gram-positive microorganisms, including Staphylococcus aureus ,including methicillin-susceptible and-resistant isolates but is not approved in these territories for the pneumonia indication. Vibativ is not yet available in Europe for use with skin such infections as are approved in the USA.
