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Allergy and Clinical Immunology Drug Data - A-Z (English)
Drug Class Description
Antihistamines (sedating)/ indirect-acting sympathomimetics (b2 -agonists, beta-agonists, beta-adrenoceptor stimulants).Generic Name
Chlorpheniramine [chlorphenamine], ephedrineDrug Description
Each tablet contains: Chlorphenamine maleate Ph.Eur. 10 mg Ephedrine hydrochloride Ph.Eur. 15mgPresentation
TabletsIndications
Relief of symptoms caused by allergic conditions such as hay fever, allergic rhinitis, perennial rhinitis, urticaria etc., which are responsive to antihistamine.Adult Dosage
Adults, elderly and children over 12 years of age:
One or two tablets daily. One tablet should be taken in the morning on rising and a further tablet may be taken at night if required.
Child Dosage
Not recommended.
Method of administration - oral use.
Contra Indications
Coronary thrombosis, hypertension, thyrotoxicosis and those on treatment with monoamine oxidase inhibitors.
Special Precautions
Tablets should be swallowed whole and not sucked or chewed. Do not exceed the stated dose. Asthmatics should consult their doctor before using this product. May cause drowsiness, if affected do not drive or operate machinery. Avoid alcoholic drink.
Interactions
Alcoholic drinks and certain other central nervous system depressants can potentiate any sedative effect.
Adverse Reactions
Although the combination of ephedrine with the anti-histamine chlorphenamine is intended to reduce side-effects, slight drowsiness may occur. Side effects of ephedrine are rare at the low dose employed in this preparation, however in particularly susceptible patients, effects such as giddiness, palpitations and muscular weakness may be experienced transiently.
Manufacturer
Chemidex Pharma LtdDrug Availability
(P)Updated
14 May 2009Advert for Healthcare Professionals Only
Related News
Study finds benefits of Xolair for Allergic Asthma treatment Allergy and Clinical Immunology Page
New results from the APEX trial of Xolair (omalizumab), from Novartis, show that the drug considerably reduces patients need for steroid use, while at the same time helping disease control and lowering the amount of Asthma exacerbations. Usual treatment for Allergic Astham is oral steroids, but these are associated with weight gain, hypertension, osteoporosis and depression. The data, presented at the 2011 European Respiratory Society congress, shows that in the 12 months after patients started on Xolair (p<0.001), the mean total dose of oral corticosteroids per individual reduced by 34%, with 49% of individuals stopping the oral steroids altogether and 64% considerably reducing their oral corticosteroid dosage. Compared to the previous year, patients experienced a considerable reduction in the amount of asthma exacerbations after 12 months of treatment (53%, 1.7 versus 3.7, 95% CI, p<0.001). Lung function was also found to improve.
