17 Jun 2009

XEFO (Lornoxicam) - United Kingdom

Updated: 17 Jun 2009

XEFO

Short-term treatment of moderate postoperative pain, such as pain after dental surgery. Treatment of pain associated wih acute lumbo-sciatia. Symptomatic treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis.

XEFO Description, Presentation and Dosage

XEFO Description

XEFO Drug Class Description

Non-steroidal anti-inflammatory drugs

XEFO Drug Description

Film-coated tablets.

XEFO Generic Name

Lornoxicam

XEFO Presentation

XEFO Presentation

Tablets, lornoxicam 4mg, 8mg.

XEFO Manufacturer

CeNeS

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XEFO Dosage

XEFO Adult Dosage

Postoperative pain/acute lumbo-sciatia, recommended daily dose, 8mg to 16mg taken before meals (daily doses above 8mg should be divided into two or more doses).

Maximum single dose, 8mg; maximum daily dose, 16mg. Osteoarthritis/Rheumatoid arthritis, recommended daily dose, 12 mg taken before meals (4mg three times daily or 8mg in the morning and 4mg at night); maximum recommended daily dose for long-term treatment, 12mg.

XEFO Child Dosage

Under 18 years, not recommended

XEFO Elderly Dosage

Monitoring of renal and heptic function is recommended.

XEFO Precautions, Reactions and Contraindications

XEFO Special Precautions

XEFO Special Precautions

In the following conditions Xefo should be administered only after careful risk-benefit asseseement. Gastrointestinal ulceration and bleeding in medical history; discontinue treatment if peptic ulceration and/or gastrointestinal bleeding occurs.

Renal impairment: mild (serum creatinine 150 to 300 micromol/l), monitor at one to two month intervals.

Blood coagulation disorders; careful monitoring recommended.

Liver disease (eg, cirrhosis); regular monitoring recommended. Long-term treatment (longer than three months), monitor haemoglobin, creatinine and liver enzymes regularly.

Elderly; monitor renal and hepatic function in patients over 65 years. Hypertension and/or obesity; monitor blood pressure and renal function. Monitor renal function in patients who are to undergo major surgery, with stressed renal function (eg, as a result of significant blood loss or severe dehydration), with cardiac failure, receiving concomitant treatment with diuretics or with drugs suspected or known to be able to cause kidney damage.

XEFO Adverse Reactions

XEFO Adverse Reactions

Most commonly (frqency 1 to 10%): abdominal pain, diarrhoea, dizziness, dyspepsia, headache, nausea, vomiting.

Rarely (frequency <1%): constipation, dysphagia, dry mouth, flatulence, gastritis, gastro-oesophageal reflux, peptic ulceration and/or gastrointestinal bleeding, stomatitis, haemorrhoidal bleeding, liver function abnormalities, alopecia, dermatitis, pruritus, increased sweating, micturition disorder, oedema, leg cramps paraesthesia, tremor, conjunctivitis, vision disorder, tinnitus, taste perversion, allergic reactions, anaemia, thrombocytopenia, increased bleeding time, ecchymoses, hypertension, palpitations, tachycardia, agitation, depression, insomnia, solnolence, alteration in appetite, weight changes, mylagia, malaise, weakness.

XEFO Contraindications

XEFO Contraindications

Allergy to lornoxicam or any of the excipients. Previous hypersensitivity reactions (symptoms like asthma, rhintis, angioedema or urticaria) to other non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin (acetylsalicylic acid). Active peetic ulceration or a history of recurrent peptic ulceration. Severe renal impairment (serum creatinine > 700 micromol/ml). Pregnancy and lactation. Patients under 18 years of age.

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