10 Dec 2014
(Paracetamol / Codeine)
- United Kingdom
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Selected content related to Tylex (Paracetamol / Codeine)
- Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin.1
Franceschi F, Iacomini P, Marsiliani D, Cordischi C, Antonini EF, Alesi A, Giacobelli D, Zuccalà G.
Eur Rev Med Pharmacol Sci. 2013 Aug;17(16):2129-35.
Background: Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED). The combination acetaminophen/codeine represents the standard medication in the second step of the WHO analgesic scale and codeine is one of the most commonly used opioid analgesic for a variety of pain conditions. However, many aspects related to safety and efficacy are still undefined.
Aim: To summarize and review the results of the most relevant studies on the efficacy and safety profile of acetaminophen/codeine combination in the treatment of pain of different origin.
Conclusions: Acetaminophen/codeine combination is effective in the treatment of pain, through a synergistic action of the two molecules, and is not inferior to NSAIDs. Side effects of acetaminophen/codeine are usually minor, differently from NSAIDs, which may induce some potentially life threatening conditions.
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- Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults.
Toms L, Derry S, Moore RA, McQuay HJ.
Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001547. doi: 10.1002/14651858.CD001547.pub2.
Background: This is an updated version of the Cochrane review published in Issue 4, 1998. Combining drugs from different classes with different modes of action may offer opportunity to optimise efficacy and tolerability, using lower doses of each drug to achieve the same degree of pain relief. Previously we concluded that addition of codeine to paracetamol provided additional pain relief, but at expense of additional adverse events. New studies have been published since. This review sought to evaluate efficacy and safety of paracetamol plus codeine using current data, and compare findings with other analgesics evaluated similarly.
Objectives: Assess efficacy of single dose oral paracetamol plus codeine in acute postoperative pain, increase in efficacy due to the codeine component, and associated adverse events.
Author's Conclusions: This update confirms previous findings that combining paracetamol with codeine provided clinically useful levels of pain relief in about 50% of patients with moderate to severe postoperative pain, compared with under 20% with placebo. New information for remedication shows that the combination extended the duration of analgesia by about one hour compared to treatment with the same dose of paracetamol alone. At higher doses, more participants experienced adequate pain relief, but the amount of information available for the 1000 mg paracetamol plus 60 mg codeine dose was small, and based on limited information.
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- Franceschi F, Iacomini P, Marsiliani D, Cordischi C, Antonini EF, Alesi A, Giacobelli D, Zuccalà G. Safety and efficacy of the combination acetaminophen-codeine in the treatment of pain of different origin. Eur Rev Med Pharmacol Sci. 2013 Aug;17(16):2129-35.
- Toms L, Derry S, Moore RA, McQuay HJ. Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001547. doi: 10.1002/14651858.CD001547.pub2.
Tylex Marketing Information
- Tylex capsules: 31/03/2008
- Tylex effervescent tablets: 05/11/2009
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