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Latest Drugs
Infectious Diseases Drug Data - A-Z (English)
Drug Class Description
Toxoid vaccines.Generic Name
Tetanus VaccinePresentation
Injection, tetanus toxoid not less than 40 i.u./0.5 mL adsorbed onto aluminium hydroxide.Indications
Active immunisation against tetanus. Reinforcement of immunity to tetanus.Adult Dosage
Primary immunisation: 3 doses of 0.5 mL by intramuscular or deep subcutaneous injection at 4 week intervals between each dose. Normally, use triple vaccine in children under 10 years. Reinforcing dose: 0 .5 mL by intramuscular or deep subcutaneous injection. 1 dose 10 years after primary course with a further dose 10 years later. Do not continue to give boosters routinely except for tetanus prone injuries.
Clean wounds: If not immunised or immunisation status unknown, give primary immunisation course. If last of 3 dose course or reinforcing dose more than 10 years previously, give reinforcing dose. If last of 3 dose course or reinforcing 3 dose course or reinforcing dose within last 10 years, no vaccine is necessary. Tetanus prone wounds: As for clean wounds PLUS tetanus immunoglobulin at a separate site.
Child Dosage
Reinforcing dose: 0 .5 mL by intramuscular or deep subcutaneous injection. 1 dose (as DT) at least 3 years after last dose of primary course with a further dose (as Td) at aged 13 - 18 yrs or before leaving school. Do not continue to give boosters routinely except for tetanus prone injuries.Contra Indications
Acute infections except in a tetanus prone wound.Special Precautions
Hypersensitivity reactions may occur particularly in those patients receiving a reinforcing dose within a year of receiving a booster.Adverse Reactions
Fever, malaise, local reactions.Manufacturer
MedevaDrug Availability
(POM)Updated
27 April 2009Advert for Healthcare Professionals Only
Related News
IlLLUMINATE trial of Incivek is published in NEJM Infectious Diseases Page
The New England Journal of Medicine (NEJM) published data from a Phase III study of Incivek(telaprevir) tablets in people with genotype 1 chronic Hepatitis C who were new to treatment. In ILLUMINATE, Incivek was given for the first 12 weeks in combination with pegylated-interferon and ribavirin. Nearly two-thirds of patients responded early to Incivek combination treatment (measured by having undetectable hepatitis C virus at weeks 4 and 12 of treatment) and were randomly assigned to receive an additional 12 weeks or 36 weeks of treatment with pegylated-interferon and ribavirin alone. Similarly high rates of sustained viral response (SVR, or viral cure) were achieved by people in both treatment groups. Rash and anemia were the most common side effects reported with Incivek in this study and each led to treatment discontinuation of all medicines in about 1 percent of people during the Incivek treatment phase. Data from ILLUMINATE are published in the September 15, 2011 issue of NEJM.
Incivek treatment still effective when course is half as long in treatment of Hepatitis C genotype 1 Infectious Diseases Page
A Phase III study (ADVANCE) of Incivek (telaprevir) tablets in patients with genotype 1 chronic Hepatitis C published in The New England Journal of Medicine (NEJM) reveals that a 24-week treatment course that adds Incivek to peginterferon alfa and ribavirin is just as effective as a 48-week regimen for many patients. Shortening the duration of treatment reduces a patient's exposure to side effects including rash and anemia.see Response-Guided Telaprevir Combination Treatment for Hepatitis C Virus Infection September 15, 2011Sherman K.E., Flamm S.L., Afdhal N.H., et al.N Engl J Med 2011; 365:1014 - 1024.
Vibativ is EU approved for nosocomial pneumonia caused by MNSA Infectious Diseases Page
Astellas and Theravance have received marketing authorisation from the European Commission for Vibativ (telavancin hydrochloride) for nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA).Its labelling will include its use in the treatment of adults with nosocomial pneumonia (hospital-acquired), including ventilator-associated pneumonia, known or suspected to be caused by MRSA when other alternatives are not suitable. In the US and Canada, the drug was approved in 2009 for the treatment of adult patients with complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of certain Gram-positive microorganisms, including Staphylococcus aureus ,including methicillin-susceptible and-resistant isolates but is not approved in these territories for the pneumonia indication. Vibativ is not yet available in Europe for use with skin such infections as are approved in the USA.
