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Latest Drugs
Diabetes and Endocrinology Drug Data - A-Z (English)
Drug Class Description
Sulphonylureas (long-acting).Generic Name
GenericDrug Description
Tablets.Presentation
Tablets, chlorpropamide 100mg , 250mg . Available from Regent.Indications
Diabetes mellitus. Diabetes insipidus.
Adult Dosage
Diabetes Mellitus: initially 250mg daily, adjusted according to response. Maximum daily dose, 500mg. Diabetes Insipidus: up to 350mg daily, taking care to avoid hypoglycaemia.
Child Dosage
Diabetes Insipidus: up to 200mg daily, taking care to avoid hypoglycaemia.Elderly Dosage
Diabetes Mellitus: initially 100 - 125mg daily, adjusted according to response. Maximum daily dose, 500mg.Contra Indications
Pregnancy.Special Precautions
Frequent monitoring of hepatic function recommended during initial therapy.Interactions
Oral anticoagulants, hydantoins, salicylates, non-steroidal anti- inflammatory drugs, sulphonamides, thiazide diuretics. Alcohol.Adverse Reactions
GI disturbances (eg, anorexia, vomiting, epigastric discomfort, constipation), neurological effects (eg, paraesthesia). Hypersensitivity reactions - occur. Cholestatic jaundice. Occasionally, blood dyscrasias. Hypoglycaemia. Rarely, photosensitivity.
Drug Availability
(POM)Updated
30 June 2009Advert for Healthcare Professionals Only
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Bydureon reduces cardiovascular risk factors in Type 2 Diabetes patients Diabetes and Endocrinology Page
Patients receiving Bydureon (exenatide extended release), a drug for Type 2 Diabetes from Amylin, Eli Lilly and Alkermes experienced significant improvements in specific cardiovascular risk factors compared to patients who received more commonly prescribed treatments. The results show that patients receiving Bydureon experienced improvements related to body weight, abnormal blood pressure and abnormal lipid levels. The analysis from the DURATION-3 trial demonstrated statistically significant reduction in body weight of 9.8 pounds compared to conventional treatment. The analysis of the DURATION-4 trial reveals the patients reached a composite endpoint of A1C <7 percent plus target systolic blood pressure (<130 mmHg) and target LDL cholesterol (<100 mg/dL) (16 percent for Bydureon vs. 10 percent for Actos, 7 percent for Januvia and 13 percent for metformin. These findings will be presented at the 47th European Association for the Study of Diabetes Annual Meeting 2011.
TAK 875 a new treatment for Type 2 Diabetes enters Phase III Diabetes and Endocrinology Page
TAK 875 from Takeda is a new selective agonist of the G-protein-coupled receptor (GPR 40)which is expressed in pancreatic islet beta cells. The drug has entered Phase III studies in Japan for Type 2 Diabetes and Phase III trials are commencing in the USA and EU. Phase II data showed a significant lower incidence of hypoglycaemia compared to placebo and to glimepiride and positive efficacy.
