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Allergy and Clinical Immunology Drug Data - A-Z (English)
Drug Class Description
Antibacterials / keratolytics.Generic Name
Benzoyl peroxideDrug Description
Benzoyl peroxide 4%w/w as hydrous benzoyl peroxide Ph Eur 100g cream contains 4g benzoyl peroxide.Presentation
Cream A white to off white cream.Indications
Brevoxyl is indicated for the treatment of moderate acne vulgaris.Adult Dosage
Adolescents and Adults:
Apply to the whole of the affected area once or twice daily. Wash with soap and water prior to application.
Paediatric use:
The safety and efficacy of Brevoxyl has not been established in children since acne vulgaris rarely presents in this age group.
Initial application of the product may be varied at the physicians instructions to reflect the patients skin type and to avoid undesirable effects.
Improvement can generally be seen after 4-6 weeks of treatment. However, longer use may be necessary.
Child Dosage
Not recommended.Contra Indications
Patients with known hypersensitivity to any of the ingredients should not use the product.
Special Precautions
Avoid contact with the eyes, mouth and other mucous membranes. Care should be taken when applying the product to the neck and other sensitive areas. Propylene glycol alginate may cause skin irritation. Stearyl alcohol and cetyl alcohol may cause local skin reaction (e.g. contact dermatitis).
It is recommended that exposure to sun or sunlamps should be minimised.
Simultaneous use of other keratolytics such as salicylates or sulphur may increase occurrence of skin irritation.
During the first weeks of treatment, a sudden increase in peeling and reddening will occur in most patients; this is not harmful and will normally subside in a day or two if treatment is temporarily discontinued.
The product may bleach hair and coloured or dyed fabrics.
Interactions
Simultaneous application of Brevoxyl and topical acne preparations containing vitamin A derivatives should be avoided.
Adverse Reactions
In normal use, a mild burning sensation will probably be felt on first application and a moderate reddening and peeling of the skin will occur within a few days. During the first few weeks of treatment, a sudden increase in peeling and reddening will occur in most patients; this is not harmful and will normally subside in a day or two if treatment is temporarily discontinued. The patient may also experience temporary pruritus, facial oedema, dermatitis or rash. As for other benzoyl peroxide preparations allergic contact dermatitis could occasionally occur.
Manufacturer
Stiefel Laboratories (UK) LimitedDrug Availability
(P)Updated
14 April 2009Advert for Healthcare Professionals Only
Related News
Study finds benefits of Xolair for Allergic Asthma treatment Allergy and Clinical Immunology Page
New results from the APEX trial of Xolair (omalizumab), from Novartis, show that the drug considerably reduces patients need for steroid use, while at the same time helping disease control and lowering the amount of Asthma exacerbations. Usual treatment for Allergic Astham is oral steroids, but these are associated with weight gain, hypertension, osteoporosis and depression. The data, presented at the 2011 European Respiratory Society congress, shows that in the 12 months after patients started on Xolair (p<0.001), the mean total dose of oral corticosteroids per individual reduced by 34%, with 49% of individuals stopping the oral steroids altogether and 64% considerably reducing their oral corticosteroid dosage. Compared to the previous year, patients experienced a considerable reduction in the amount of asthma exacerbations after 12 months of treatment (53%, 1.7 versus 3.7, 95% CI, p<0.001). Lung function was also found to improve.
