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Latest Drugs
Cardiology Drug Data - A-Z (English)
Drug Class Description
Low molecular weight heparins (LMWHs, anticoagulants).Generic Name
CertoparinDrug Description
Solution in pre-filled syringes.Presentation
Injection, certoparin 3000 i.u. anti-Factor Xa activity.Indications
Prophylaxis of peri- and post- operative venous thromboembolism.Adult Dosage
3000 i.u. daily by subcutaneous injection into the peritoneal fold 1 - 2 hours prior to surgery. Repeat once daily for 7 to 10 days or until mobile.Child Dosage
Not recommended.Contra Indications
Major bleeding disorders, bleeding ulcers of the stomach or intestine, severe hypertension (>200/120mmHg), hypersensitivity to heparin, subacute bacterial endocarditis, severe renal and/or hepatic dysfunction.
Special Precautions
Must not be administered intramuscularly. Monitor platelet counts. May cause hyperkalaemia, particularly in diabetes mellitus, chronic renal failure, mellitus, chronic renal failure, pre-existing metabolic acidosis, patients with raised plasma potassium or taking potassium- sparing drugs; measure plasma potassium before starting therapy, and monitor regularly thereafter, especially if treatment prolonged beyond 7 days. Spinal or epidural anaesthesia - risk of spinal haematomas and paralysis; observe patients carefully. Pregnancy and lactation.
Interactions
NSAIDs, oral anticoagulants, dipyridamole, dextrans, etacrynic acid (ethacrynic acid), cytostatic agents, antihistamines, digitalis, tetracyclines, ascorbic acid.
Adverse Reactions
Minor bleeding at injection site, thrombocytopenia, hypersensitivity reactions, raised liver enzymes, osteoporosis. Rarely, clinically significant hyperkalaemia. Very rarely, spinal haematomas in patients undergoing spinal or epidural anaesthesia.
Manufacturer
GrifolsDrug Availability
(POM)Updated
04 June 2009Advert for Healthcare Professionals Only
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