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Allergy and Clinical Immunology Drug Data - A-Z (English)

Drug Class Description

Macrolides / retinoids.

Generic Name

Erythromycin, tretinoin

Drug Description

Erythromycin Ph Eur 4% w/w and Tretinoin BP 0.025% w/w

Presentation

A clear solution for topical administration

Indications

For the treatment of all forms of acne, both non-inflammatory forms with comedones and inflammatory forms with papules and pustules particularly those associated with a very oily skin.

Adult Dosage

To be applied to the affected areas once or twice daily. Treatment should continue for 9-12 weeks according to the condition of the skin. It should be noted that therapeutic improvement may not be observed for several weeks after starting treatment.

Excess application of Aknemycin Plus should be avoided since it may result in marked erythema, drying and discomfort of the treated areas.

The dosage is the same for all ages.

Child Dosage

As for adults.

Contra Indications

Hypersensitivity to the active ingredients. A family history of cutaneous epithelioma. In acute eczemas, rosacea and acute inflammatory conditions of the skin, especially around the mouth. When underlying sunburn is present, concomitantly with other skin medications particularly those containing keratolytic agents.

Special Precautions

Exposure to sunlight should be minimised and use of sun lamps avoided during treatment. Patients with sunburn should not use this product until recovered because of the increased susceptibility to sunlight whilst using tretinoin. Wind and rain may be unusually irritating to patients under treatment.

Accumulation of the product in skin folds or in the angles of the nose should be avoided.

The product should not be allowed to come into contact with the eyes or eyelids - if this occurs, thorough rinsing with water is recommended.

Interactions

Skin irritation may be enhanced by UV rays, X-rays or by bathing in chlorinated or salt water.

Aknemycin Plus should not be used concomitantly with other skin medications particularly those containing keratolytic agents.

Adverse Reactions

Skin irritation in the form of erythema, burning, drying or peeling of the skin may be observed. There may be an apparent deterioration in acne with an increase in inflammatory symptoms at the commencement of treatment; this is usually transitory. If the above occurs, treatment should not be interrupted but the frequency of application reduced.

A temporary hypopigmentation or hyperpigmentation has been reported in a few individuals treated with tretinoin. Temporary depigmentation in non-caucasians is possible.

Manufacturer

Almirall Limited

Drug Availability

(POM)

Updated

04 June 2009
Drug Languages: en it fr de es no nl pt se

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AKNEMYCIN PLUS