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Latest Drugs
Cardiology Drug Data - A-Z (English)
Drug Class Description
ACE inhibitors.Generic Name
Captopril - hypertension/diabetesDrug Description
12.5 mg, white scored capsule- shaped tablet marked ACE and 12.5; 25 mg, 50 mg white scored tablets marked ACE and tablet strength.Presentation
Tablets, captopril 12.5mg , 25mg , 50mg .Indications
Mild to moderate hypertension. Severe hypertension where standard therapy is ineffective or inappropriate. Diabetic nephropathy in insulin dependent diabetes.
Adult Dosage
Mild to moderate hypertension
Initially 12 .5 mg twice daily. Maintenance, 25 mg twice daily increasing gradually at 2 - 4 week intervals if necessary to maximum 50 mg twice daily.
Severe hypertension
Initially 12.5 mg twice daily increasing if necessary to maximum 50 mg three times daily. Diabetic nephropathy, 75 - 100 mg daily in divided doses.
Child Dosage
Contact manufacturer.Contra Indications
- Obstruction
- Pregnancy
- lactation.
Special Precautions
Renovascular hypertension
severe congestive heart failure. Haemodialysis.
Renal impairment
monitor renal function, white cell count and urinary protein before and during therapy.
Collagen vascular disease
Anaesthesia. Elderly.
Interactions
- K+-sparing diuretics or K+ supplements
- NSAIDs
- vasodilators
- clonidine
- allopurinol
- procainamide
- probenecid
- immunosuppressants
- lithium
- antidiabetic agents
- neuroleptics
- tricyclic antidepressants
- antihypertensives.
Adverse Reactions
- Neutropenia
- Agranulocytosis
- Thrombocytopenia
- Anaemia
- Proteinuria
- Hypotension
- Angioedema
- Rash
- Loss of taste
- Pancreatitis
- Tachycardia
- Gastric irritation
- Cough (rare).
Manufacturer
Bristol-Myers Squibb / AshbourneDrug Availability
(POM)Updated
22 June 2009Advert for Healthcare Professionals Only
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