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Heart Failure

Heart Failure

Heart failure (HF) is a complex disorder whereby the heart becomes progressively unable to pump blood efficiently to the tissues of the body. The Heart Failure Knowledge Centre focuses on the pathophysiology, diagnosis and management of chronic and post myocardial infarction (post-MI) heart failure.

Risk factors for ACS, and subsequently post-MI heart failure, are usually the clinical consequence of the formation of an occlusive thrombus at the site of a ruptured or eroded atherosclerotic plaque in a coronary artery. These can be modifiable (smoking,1 obesity,1 lack of exercise,1 hypertension,1,2 hyperlipidaemia,2,3 diabetes mellitus3) and non-modifiable (increased age1, male gender1, family history1,2) risk-factors.

The Heart Failure Knowledge Centre aims to provides healthcare professionals with the tools to diagnose and manage patients with both chronic and post-MI heart failure in line with current ESC guidelines.


References

  1. Kumar P, Clark M. Clinical medicine. 7th ed. Edinburgh: Saunders Elsevier, 2009.
  2. Graham I, Atar D, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur J Cardiovasc Prevent Rehab 2007;14 Suppl. 2:E1-40.
  3. Zeljko Reiner, Alberico L. Catapano, Guy De Backer et al. ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J first published online June 28, 2011 doi:10.1093/eurheartj/ehr158.

Clinical Case Studies

Pulmonary Hypertension

Respiratory Medicine & Allergy: Pulmonary Vascular Diseases

Bethia Bradley, Specialist Registrars in Respiratory Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK
Richard Leach, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 26-year-old woman presented to the chest clinic with a two-year history of slowly progressive exertional dyspnoea. At presentation she was experiencing difficulty walking up inclines, keeping up with friends when walking on the flat, climbing two flights of stairs and cleaning the house.

MRSA Endocarditis

Infection: Cardiovascular Infections

Christopher D. Pfeiffer, Clinical Fellow, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Vance Fowler, Associate Professor and Infectious Diseases, Specialist, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA

Case History
A 64-year-old female presented with three weeks of progressive dyspnoea, nausea and vomiting.

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Apr 2015

The aim of this guideline is to provide advice, based on clinical evidence where available,..

... regarding the prevention of venous thromboembolism (VTE) during pregnancy, birth and following delivery.

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Apr 2015

The aim of this guideline is to provide information, based on clinical evidence where available,..

... regarding the immediate investigation and management of women in whom venous thromboembolism is suspected during pregnancy or the puerperium.

Online CME

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After completing this module you should be able to: describe the classification of bradycardias, describe the common causes of different types of bradycardia, and recognise typical electrocardiograms (ECGs).

Peripheral arterial disease: an update on management

On completion of this module you should know: The incidence and prevalence of peripheral arterial disease. How best to treat it. What information to give to patients about prognosis.

Stroke prevention in atrial fibrillation

On completion of this module you will understand more about: risk factors and screening, calculating risk, anticoagulation and falls and therapy.

Clinical Trials

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Mon 17 Nov 2014

The purpose of this study is to document safety and efficacy of renal sympathetic denervation treatment in subjects with uncontrolled hypertension by using Iberis renal denervation ...

Cryoballoon Ablation in Patients With Longstanding Persistent Atrial Fibrillation (CRYO-LPAF)

Wed 12 Nov 2014

Prospective and explorative clinical study. The objective is to assess the clinical efficacy of pulmonary vein isolation using the Arctic Front Advance cryoballoon in patients with longstanding ...

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