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Heart Failure

Heart Failure

Heart failure (HF) is a complex disorder whereby the heart becomes progressively unable to pump blood efficiently to the tissues of the body. The Heart Failure Knowledge Centre focuses on the pathophysiology, diagnosis and management of chronic and post myocardial infarction (post-MI) heart failure.

Risk factors for ACS, and subsequently post-MI heart failure, are usually the clinical consequence of the formation of an occlusive thrombus at the site of a ruptured or eroded atherosclerotic plaque in a coronary artery. These can be modifiable (smoking,1 obesity,1 lack of exercise,1 hypertension,1,2 hyperlipidaemia,2,3 diabetes mellitus3) and non-modifiable (increased age1, male gender1, family history1,2) risk-factors.

The Heart Failure Knowledge Centre aims to provides healthcare professionals with the tools to diagnose and manage patients with both chronic and post-MI heart failure in line with current ESC guidelines.


References

  1. Kumar P, Clark M. Clinical medicine. 7th ed. Edinburgh: Saunders Elsevier, 2009.
  2. Graham I, Atar D, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur J Cardiovasc Prevent Rehab 2007;14 Suppl. 2:E1-40.
  3. Zeljko Reiner, Alberico L. Catapano, Guy De Backer et al. ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J first published online June 28, 2011 doi:10.1093/eurheartj/ehr158.

Clinical Case Studies

Sickle Cell Lung Disease

Respiratory Medicine & Allergy: Pulmonary Vascular Diseases

Elizabeth Hadley, Consultant Respiratory and General Physician, Barking, Havering and Redbridge Hospitals University NHS Trust, London, UK
Boris Lams, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK
Christopher Kosky, Consultant Respiratory Physicians, Guy's and St Thomas' NHS Foundation Trust, London, UK

Case History
A 40-year-old man with known homozygous (HbSS) sickle cell disease (SCD) presented to the emergency department with a three-day history of cough, fever and sweats. He denied any chest pain.

Pulmonary Arteriovenous Malformation

Respiratory Medicine & Allergy: Pulmonary Vascular Diseases

Elizabeth Hadley, Consultant Respiratory and General Physician, Barking, Havering and Redbridge Hospitals University NHS Trust, London, UK

Case History
A 45-year-old lady was referred to the chest clinic because of dyspnoea. She had gradually become more breathless over two years and was now breathless at rest.

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Medical Images

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Pulmonary arteriovenous malformation
 Pulmonary arteriovenous malformation
Chest radiograph of sickle cell lung disease
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Sickle cell lung disease
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Clinical Guidelines

Reducing the Risk of Venous Thromboembolism during Pregnancy and the Puerperium

Apr 2015

The aim of this guideline is to provide advice, based on clinical evidence where available,..

... regarding the prevention of venous thromboembolism (VTE) during pregnancy, birth and following delivery.

Thromboembolic Disease in Pregnancy and the Puerperium: Acute Management

Apr 2015

The aim of this guideline is to provide information, based on clinical evidence where available,..

... regarding the immediate investigation and management of women in whom venous thromboembolism is suspected during pregnancy or the puerperium.

Online CME

Bradycardia: diagnostic picture tests

After completing this module you should be able to: describe the classification of bradycardias, describe the common causes of different types of bradycardia, and recognise typical electrocardiograms (ECGs).

Peripheral arterial disease: an update on management

On completion of this module you should know: The incidence and prevalence of peripheral arterial disease. How best to treat it. What information to give to patients about prognosis.

Stroke prevention in atrial fibrillation

On completion of this module you will understand more about: risk factors and screening, calculating risk, anticoagulation and falls and therapy.

Clinical Trials

DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury

Sun 01 Mar 2015

Heart attacks are most commonly caused by rupture of fatty deposits (plaques) within the wall of heart blood vessels. It appears that this process can also frequently occur without causing any ...

Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source (ESUS) (NAVIGATE ESUS)

Mon 01 Dec 2014

This is a study in patients who recently had a brain attack (stroke) and in whom no clear cause of the stroke could be identified. These strokes are likely due to a blood clot and therefore, can be ...

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