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  • Anesthesiology - Disease Topic Overview

    Anaesthesiology is the medical speciality that encompasses study and use of anaesthesia; general, regional and local.

    Historically surgery was performed without adequate pain relief, usually following the administration of alcohol, which was ineffective as an analgesic. In the mid 19th Century the discovery of the pain relieving properties of nitrous oxide by Horace Wells, and ether by William Morton, led to the birth of modern anaesthesia. The main benefit of ether was that, in a vaporised form, it did not cause respiratory depression and allowed the airway to be kept open by inexperienced anaesthetists.1

    General anaesthesia uses chemicals to produce an unconscious state in which a patient has no perception of pain and will have no memory of the procedure upon regaining consciousness.2 This is used primarily during major surgery, however there are more dangers with this type of anaesthesia; namely reduced respiratory and heart rate, blood pressure and body temperature.3

    Regional and local anaesthesia are used in minor surgery to block the perception of pain without causing loss of consciousness. This has the benefit of allowing some outpatient procedures which have lower waiting times4, require shorter hospital stays and have shorter recovery periods.5 Regional anaesthetics are used to block the sodium gated channels of specific nerves to inhibit the production of an action potential.6 Nerve blocking can be used in both the central nervous system and peripheral nervous system and causes the numbing of regions of the body. Epidural anaesthesia is often used for surgeries of the lower body (bladder, leg, gynaecological and prostate).3 Local anaesthetics are injected into the specific area where the incision will occur. This has the benefit of faster recovery and reduced risk of anaesthetic complications.

    1. Jacob A. et al. The History of Anesthesia. Clinical Anesthesia Sixth Edition. Lippincott Williams and Wilkin. 2009 : 3-7.
    2. Alkire M. General Anesthesia. Encyclopedia of Consciousness. Elsevier Inc. 2009 : 295-313.
    3. Beers M.H. et al. The Merck Manual of Medical Information. Merck research laboratories. Second home edition. 2003 : 1699-1700.
    4. Trentmen T. et al. Outpatient Surgery Performed in an Ambulatory Surgery Center Versus a Hospital: Comparison of Perioperative Time Intervals. The American Journal of Surgery. 2010 ; 200 (1) : 64-67.
    5. Rueben S. A Comparison of Local Intraarticular Anesthesia Versus General Anesthesia For Ambulatory Arthroscopic Knee Surgery. Ambulatory Surgery. 2005 ; 12 (1) : 39-44.
    6. Liu S. et al. Local Anesthetics. Clinical Anesthesia Sixth Edition. Lippincott Williams and Wilkin. 2009 : 531.

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Anesthesiology Drug Data - A-Z English

Drug Updates

As an analgesic supplement for use before and during anaesthesia. Tracrium is a highly selective, competitive or non-depolarising neuromuscular blocking agent. Anexate is indicated for the complete or partial reversal of the central sedative effects of benzodiazepines.

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Latest Clinical Trials

The primary objectives of this study are to demonstrate either non-inferior pain relieving effects of the modified-release formulation of flupirtine (400mg OD in the evening) in comparison to extended-release tramadol (200mg OD in the evening) as well as a superior analgesic efficacy of flupirtine MR (400mg OD in the evening) in comparison to placebo in patients suffering from moderate to severe chronic low back pain (CLBP) after a four week treatment course.
The primary objective of this study is to assess the efficacy of duloxetine 60 mg once daily (QD) to 120 mg QD compared with placebo on the reduction of pain severity as measured by the weekly mean of the 24-hour average pain scores in patients with chronic low back pain (CLBP) during a 13-week, double-blind acute treatment period using an 11-point Likert scale and an electronic patient diary.

Latest Journal Publications

Background: Remifentanil and propofol are increasingly used for short-duration procedures in spontaneously breathing patients. In this setting, it is preferable to block the response to moderate stimuli while avoiding loss of responsiveness (LOR) and intolerable ventilatory depression (IVD). In this study, we explored selected effects of combinations of remifentanil-propofol effect-site concentrations (Ces) that lead to a loss of response to esophageal instrumentation (EI), LOR, and/or onset of IVD. A secondary aim was to use these observations to create response surface models for each effect measure. We hypothesized that (1) in a large percentage of volunteers, selected remifentanil and propofol Ces would allow EI but avoid LOR and IVD, and (2) the drug interaction for these effects would be synergistic. Methods: Twenty-four volunteers received escalating target-controlled remifentanil and propofol infusions over ranges of 0 to 6.4 ng · mL−1 and 0 to 4.3 μg · mL−1, respectively. At each set of target concentrations, responses to insertion of a blunt end bougie into the midesophagus (40 cm), level of responsiveness, and respiratory rate were recorded. From these data, response surface models of loss of response to EI and IVD were built and characterized as synergistic, additive, or antagonistic. A previously published model of LOR was used. Results: Of the possible 384 assessments, volunteers were unresponsive to EI at 105 predicted remifentanil-propofol Ces; in 30 of these, volunteers had no IVD; in 30, volunteers had no LOR; and in 9, volunteers had no IVD or LOR. Many other assessments over the same concentration ranges, however, did have LOR and/or IVD. The combinations that allowed EI and avoided IVD and/or LOR primarily clustered around remifentanil-propofol Ces ranging from 0.8 to 1.6 ng · mL−1 and 1.5 to 2.7 μg · mL−1, respectively, and to a lesser extent approximately 3.0 to 4.0 ng · mL−1 and 0.0 to 1.1 μg · mL−1, respectively. Models of loss of response to EI and IVD both demonstrated a synergistic interaction between remifentanil and propofol. Conclusion: Selected remifentanil-propofol concentration pairs, especially higher propofol-lower remifentanil concentration pairs, can block the response to EI while avoiding IVD in spontaneously breathing volunteers. It is, however, difficult to block the response to EI and avoid both LOR and IVD. It may be necessary to accept some discomfort and blunt rather than block the response to EI to consistently avoid LOR and IVD.
Assessment of diastolic function should be a component of a comprehensive perioperative transesophageal echocardiographic examination. Abnormal diastolic function exists in >50% of patients presenting for cardiac and high-risk noncardiac surgery, and has been shown to be an independent predictor of adverse postoperative outcome. Normalcy of systolic function in 50% of patients with congestive heart failure implicates diastolic dysfunction as the probable etiology. Comprehensive evaluation of diastolic function requires the use of various, load-dependent Doppler techniques This is further complicated by the additional effects of dehydration and anesthetic drugs on myocardial relaxation and compliance as assessed by these Doppler measures. The availability of more sophisticated Doppler techniques, e.g., Doppler tissue imaging and flow propagation velocity, makes it possible to interrogate left ventricular diastolic function with greater precision, analyze specific stages of diastole, and to differentiate abnormalities of relaxation from compliance. Additionally, various Doppler-derived ratios can be used to estimate left ventricular filling pressures. The varying hemodynamic environment of the operating room mandates modification of the diagnostic algorithms used for ambulatory cardiac patients when left ventricular diastolic function is evaluated with transesophageal echocardiography in anesthetized surgical patients.

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Anesthesiology